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Table
-1
Chemicals
groups of chemical or mixtures evaluated in the IARC Monographs Volumes
1-63 for which exposures are mostly occupational (excluding pesticides
and drugs)-IARC group1, carcinogenic to humans
|
AGENT
(1)
|
TARGET
ORGAN (S)
|
MAIN
INDUSTRY/ USE
|
| |
|
|
|
4-Aminobiphenyl [92-67-1]
|
Bladder
|
Rubber manufacture
|
| |
|
|
|
Arsenic [7440-38-2] and arsenic compounds (2)
|
Lung, skin
|
Glass, metals, pesticides
|
| |
|
|
|
Asbestos [1332-21-4]
|
Lung, pleura peritoneum
|
Insulation, filter material textile
|
| |
|
|
|
Benzene [71-43-2]
|
Leukaemia
|
Solvent fuel
|
| |
|
|
|
Benzidine [92-87-5] Laboratory agent
|
Bladder
|
Dye/pigment manufacture
|
| |
|
|
|
Beryllium [7440-41-7] and beryllium compounds (1993)
|
Lung
|
Aerospace industry/metals
|
| |
|
|
|
AGENT
(1)
|
TARGET
ORGAN (S)
|
MAIN
INDUSTRY/ USE
|
| |
|
|
|
Bis (chloromethyl) ether [542-88-1] and chloromethyl methyl ether
[107-30-2] (technical-grade)
|
Lung
|
Chemical intermediate/by product
|
| |
|
|
|
Cadmium [7440-43-9] and cadmium compounds (1993)
|
Lung
|
Dye/ pigment manufacture
|
| |
|
|
|
Chromium [VI] compounds (1990)
|
Nasal cavity, lung
|
Metal plating dye/ pigment manufacture
|
| |
|
|
|
Coal-tar pitches [65996-93-2]
|
Skin, lung, bladder
|
Building material, electrodes
|
| |
|
|
|
Coal tars [8007-45-2]
|
Skin, lung
|
Fuel
|
| |
|
|
|
Ethylene oxide [75-21-8]
|
Leukaemia
|
Chemical intermediate sterilant
|
| |
|
|
|
Mineral oil untreated and mildly treated
|
Skin
|
Lubricants
|
| |
|
|
|
AGENT
(1)
|
TARGET
ORGAN (S)
|
MAIN
INDUSTRY/ USE
|
| |
|
|
|
Mustard gas (sulfur mustard) [505-60-2]
|
Pharynx lung
|
War gas
|
| |
|
|
|
2-Naphthylamine [91-59-8]
|
Bladder
|
Dye/ pigment manufacture
|
| |
|
|
|
Nickel compounds (1990)
|
Nasal cavity lung
|
Metallurgy alloys catalyst
|
| |
|
|
|
Shale oils [68308-34-9]
|
Skin
|
Lubricants fuels
|
| |
|
|
|
Soots
|
Skin, lung
|
Pigments
|
| |
|
|
|
Talc containing asbestiform fibres
|
Lung
|
Paper paints
|
| |
|
|
|
Talc containing asbestiform fibres
|
Lung
|
Paper paints
|
| |
|
|
|
Vinyl chloride [75-01-4]
|
Liver lung blood vessel
|
Plastic monomer
|
| |
|
|
|
Wood dust (1994)
|
Nasal cavity
|
Wood industry
|
Notes:
(1) Year in brackets: year in which the evaluation was made subsequent
to the 1987 supplement 7 working group for agents mixtures or exposures
circumstances considered in volumes 43-63 of the monographs number in
square brackets: CAS Registry No.
(2) This evaluation applies to the group of chemicals as a whole and
not necessarily to all individual chemicals within the group.
Note:
1) Asbestos Cement (A.C) Industry is not listed as carcinogenic.
Though 80% of the asbestos fibre consumed goes into this industry.
2) Almost all modern industries are listed as carcinogenic but not Asbestos
Cement (A.C)!!
Reference:
1) International Agency for Research on Cancer. IARC
Monograph on the evaluation Of carcinogenic risks to Human Volumes 1-63,
Lyon, IARC 1972-1995.
2) Pott P.Chirurgical observation London Hawes Clarke and Collins 1775.
3) Rhen L. Blasengesch wulste beu Fuchein-Arbeitern Arch Klin Chir 1895;50;588-600
4) Sankaranarayanan R,Wahrendorf J, Demaret E.Directory On going research
in cancer Epidemiology 1994 (IARC Sci. Publ. No. 130). Lyon, IARC 1994.
5) Pearce N, Matos E, Vainio H, Boffetta P, Kogevinas M. Occupational
Cancer in developing countries (IARC Sci Publ. No. 129). Lyon IARC 1994.
6) Schulte PA, Perera FP, Molecular Epidemiology: Principles and Practices
San Diego, Academic Press, 1993.
7) Perera FP, Santella R. Carcinogenesis. In:Schulte PA, Perera FP,
eds. Molecular Epidemiology: Principles and Practices. San Diego, Academic
Press 1993,277-300.
8) Caporaso N. Hayes RB, Dosemeci M et al, Lung Cancer Risk, occupational
Exposure and the Debrisoquine Metabolic Phonotype, Cancer Res 1989;49;3675-3679.
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